50 Schoolhouse Rd. Somerset, NJ 08873 USA Phone: 732 564-0400 Fax: 732 564-0444 sales@cozzoli.com

Pharmaceutical Aseptic Equipment

Custom engineering and precision construction characterize every offering in Cozzoli's comprehensive equipment line – from nozzles and PLC components to stand alone machines all the way to complete cleaning, filling, and closing systems.

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Vial/Ampule Washing
Cozzoli's in-depth knowledge of glassware preparation and processing technology brings a new dimension to aseptic air cleaning and washing.

AW Series with Universal Vial Carriers
Functions: Air Cleaning/Washing
Container movement: continuous
Container size: 1ml - 1 liter
Speed: up to 30,000 containers/hour
Vials per carrier: 12 - 25
Wash time: programmable
Washer

Universal vial carriers dramatically reduce changeover time while segregated wash stations prevent cross-contamination. The AW Series also features air-vacuum pre-cleaning, full penetration of nozzles without vial interior contact, flexible wash sequence and low WFI consumption.

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GW Series
Functions: High production batch washing
Container handling: batch quantities
Container size: 1ml - 500ml ampules and vials
Production output: up to 23,000 containers/hour
Wash time: programmable
Washer
This high production batch washer features user programmable wash cycles with coded access and direct loading from shrink-wrap packages. Handles various media including sterile air, water and steam. Changeover is quick and easy and the GW Series is exceptionally low maintenance.
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LHR4 Manual Rotary Washer
Functions: washer
Container movement: manual
Containers handled: ampules, vials, bottles
Production output: up to 750 containers/hour (approx.)
Washer
Speeds and simplifies the task of cleaning ampules, vials, bottles and other containers. For use in sink or drain basin.
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Stopper Washing
Cozzoli's in-depth knowledge of stopper preparation and processing technology brings a new dimension to aseptic air cleaning and washing.

SW40 Programmable Vial Stopper Washing Machine
Functions: Sterile Air, Water & Silicone
Production output: 23,000/13mm stoppers, 6,200/20mm stoppers
Wash time: Programmable
Washer
The stopper washing machine, Model SW40, offers accurate repeatable washing cycles and innovative design features - like user-programmable wash cycles with coded access, sanitary supply plumbing, stainless steel exterior, and lots more!
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Liquid Filling
Choose from a variety of filling methods to meet your production goals. We offer in-line or rotary filling with piston, diaphragm pump, or time/pressure technology. Our machines handle a broad range of container shapes and fill viscosities from aqueous to heavy creams. Choose continuous or intermittent motion; standalone or monoblock configuration. Every Cozzoli liquid filler provides unmatched ease of container handling and changeover.

Liquid Filling

In-Line Liquid Filling

LF Series
Functions: fill
Container movement: continuous
Speed: up to 300 containers/minute
Number of syringes: up to 16
Accuracy: ± 0.5%
LF Dual The LF Series of walking beam fillers can be furnished with two to twelve syringes providing a fully automatic, continuous motion operation. Ideally suited for problem-free filling of most unstable containers with small openings.
Machine Shown in Dual Lane Configuration, Monoblocked with RS400 Stoppering Machines.
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VR Series
Functions: fill
Container movement: intermittent
Speed: up to 400 containers/minute
Number of syringes: 2 - 16
Accuracy: ± 0.5%
VR

The VR Filler Series encompasses different models to accommodate a variety of applications. They operate in an intermittent mode ranging from moderate to high speeds. Solid, reliable performance at low to high speeds with smooth, efficient container handling.

VR

Model VR540 Shown
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Series F400X Liquid Filler
Functions: fill
Container movement: manual
Container handling: manual
Containers handled: variety
Speed: up to 50 containers/minute depending on operator
Number of fill stations: 1 - 2
Accuracy: ± 0.5%
F400X-CE Perfect for low production rates with high accuracy requirements. Fills aqueous solutions to light oils. All product contact parts are easily disassembled for autoclaving. Shipped fully assembled and ready to use. Big features, small package.
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Series F300 Liquid Filler
Functions: fill
Container movement: manual
Containers handled: variety
Speed: up to 100 containers/minute depending on operator
Number of fill stations: 1 - 5
Accuracy: ± 0.5%
Five different models handle greater quantities of product with accuracy and precision. Shipped ready-to-use in manual or semi-automatic modes.
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TPF Series
Functions: Time Pressure Filling
Container movement: Continuous or Intermittent
Containers handled: Vials
Speed: Up to 200 Containers per Minute
LF Dual Time pressure filling is accomplished by controlling the flow of product through tubing. The product stays in a manifold that feeds the tubes. A computer calculates the product flow time needd based upon manifold pressure, nozzle size and target fill volume.
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In-Line Monoblock Filling & Stoppering

LF/S Series
Functions: fill, stopper
Container movement: continuous
Speed: up to 300 vials/minute
Number of fill stations: From 2 to 12
Accuracy: ± 0.5%
Closures handled: conventional & slotted stoppers
LF Dual For problem-free filling of most unstable containers or those with small openings, the LF/S Series offers in-line liquid filling and stoppering with smooth, efficient container handling.
Shown here is a dual lane LF/S, which can double your production output rates.
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VR/S Series
Functions: fill, stopper
Container movement: intermittent
Speed: up to 300 containers/minute
Number of syringes: 8 - 12
Accuracy: ± 0.5%
Closures handled: conventional & slotted stoppers
VR Our stainless steel in-line monoblock VR/S Series, fills and stoppers a wide variety of liquid products offering high-speed performance with smooth, efficient container handling.

Rotary Monoblock Filling & Stoppering

CR Series
Functions: fill, stopper
Container movement: continuous
Speed: up to 400 vials/minute
Number of nozzles: 6 - 12
Accuracy: ± 0.5%
Closures handled: conventional & slotted stoppers
CR400 For continuous-motion filling and stoppering of liquid pharmaceuticals, our CR Series offers high speeds at a volumetric accuracy of better than +/- 0.5% with either full or partial insertion of stoppers. Compact size requires less than 37 sq.ft. (3.4m2) of floor space.
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RFPC/REFPC Series
Functions: fill, plug or stopper, screw cap or aluminum crimp seal
Container movement: intermittent
Speed: up to 200 vials/minute
Number of nozzles: 1 - 4
Accuracy: ± 0.5%
Closures handled: wipers, opthalmic plastic, stem plug, eyedropper, aluminum seal
REFPC

The RFPC/REFPC Series can handle various container shapes and sizes and a wide range of products from aqueous to heavy oils, suspensions and creams. REFPC models permit pre-programming container size and fill volume with visual on-screen data and diagnostic reporting.

RFPC

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Mini Monoblock
Functions: Unscramble, Fill and Stopper Vials
Container movement: Continuous
Container handling: Starwheel
Containers handled: Vials
Container size: Up to 100 ml
Speed: 60 Containers per Minute
Number of fill stations: 2
Accuracy: +\- 1/2 of 1% of Fill Volume
Monoblock version: Yes
Production output: 60 Containers Per Minute
Stopper movement: Continuous
FSVP50

The newest addition to Cozzoli Machine Company's line of equipment, the Mini Monoblock was designed to acommodate a compact space, with hood isolation and laminar flow in mind, utilizing the least amount of space for use in a clean environment. This machine will fill liquids or powders, then stopper the containers using full or partial stopper insertion.

FSV

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Ampule Filling & Sealing
The multifaceted line of Cozzoli ampule and vial machines accommodate a full range of products from aqueous solutions to heavy oils, suspensions and creams. Versatility, simplicity of design, accessibility of parts and minimal changeover time contribute to the successful operation of the dependable machines.

FSV Series
Functions: unscramble, flush, fill
Container movement: intermittent
Containers handled: vials
Speed: 15 - 110 vials/minute
Number of syringes: 1 - 2
Accuracy: ± 0.5%
Monoblock version: FSV/RS100, RS200, PS10
Closures handled: conventional, slotted
Filler Our classic FSV Series of compact monoblock machines provides consistent, high-quality performance on a common frame, saving valuable floor space.
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FPS Series
Functions: unscramble, flush, fill, flush, flame seal
Container movement: intermittent
Containers handled: ampules, glass tubes, onion skin tubes, vials
Speed: 15 - 120 containers/minute
Number of syringes: 1 - 2
Accuracy: ± 0.5%
Monoblock version: FPS1/RS100, PS10, FPS2/RS100, PS10
Closures handled: conventional, slotted

Our FPS Series is ideal for filling and sealing ampules and feature stainless steel construction. They are designed with a sealed top cover plate to ensure the internal drive mechanism remains free of extraneous matter.

FPS

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FS Series
Functions: unscramble, flush, fill, flush, flame seal, tray load
Container movement: intermittent
Containers handled: ampules, vials
Speed: 15 - 220 containers/minute
Number of syringes: 2 - 4
Accuracy: ± 0.5%
The FS Series has a uniquely designed in-feed, discharge and traverse beam system to assure smooth operation.
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FC2
Functions: unscramble, flush, fill, flush, cap
Container movement: intermittent
Containers handled: cartridges and disposable syringes
Speed: 30 - 120 containers/minute
Number of syringes: Number of syringes:
Accuracy: ± 0.5%
Closures handled: combination aluminum seals (caps)
The FC2 is designed to fill and cap prestoppered dental cartridges.

In-Line Powder Filling
Cozzoli's PF Series powder fillers feature a unique dual-level supply hopper and agitator that provides just enough material of uniform density to supply the dosing chamber of each filling head. This design promotes the highest level of performance for repeatability. When dosing is completed, a brief high-pressure pulse cleans residue powder from within the dosing chamber and filter, directing it into the container -- thus eliminating product lost to waste.

PF Series
Functions: fill and stopper
Container movement: intermittent
Speed: up to 300 containers/minute
Number of fill stations: 2 - 12
Accuracy: ± 1.0% (depending on powder characteristics)
Monoblock version: PF/S Series
Closures handled: conventional, slotted
PF6

Our PF Series powder fillers feature a unique dual-level supply hopper and agitator that provides just enough material of uniform density to supply the dosing chamber of each filling head. This design promotes the highest level of performance for repeatability.

 

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PF2-TT Table-Top Powder Filler
Functions: fill
Container movement: manual
Containers handled: vials
Speed: up to 50 containers/minute
Number of fill stations: 2
Accuracy: ± 1%
PF2-TT

Totally enclosed product pathway with no abrading parts ensures zero powder contamination. Fine tuning fill-volume adjustments can be made on the fly without tools. This machine is perfect for labs or limited production facilities.

PF2-TT

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PF/S Series Monoblock
Functions: fill, stopper
Container movement: intermittent
Containers handled: vials
Speed: up to 300 containers/minute
Number of fill stations: 2 - 12
Accuracy: ± 1.0% (depending on powder characteristics)
Closures handled: conventional, slotted
Our patented PF/S Series of powder filling machines minimize waste, prevents product contamination and simplifies the validation process. These machines bring a new dimension to sterile powder filling.
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Capping/Sealing/Stoppering
Cozzoli's technical expertise is evident throughout our diverse line of stoppering, plugging, capping and sealing equipment. Outstanding design advances like our inclined rotary stoppering head and high-speed crimp sealing machine continue to improve production rates wherever they are installed. Whether manual, semi- or fully-automatic, our precision closing machinery provides reliable day-to-day operation designed to save time and aid in increasing plant utilization and efficiency.

HS1 Ampule and Tube Hand Sealer
Functions: tip seal, pull seal
Container movement: manual
Closures handled: ampules, tubes
Production output: up to 800 containers/hour
HS1 An efficient way to seal filled ampules or straight wall tubes. This machine will efficiently tip or pull seal ampules or tubes, and is ideal for lab or limited production facilities.
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SC50T Screw Capping
Functions: screw caps, aluminum crimp seal
Container movement: manual
Closure sizes: up to 95mm diameter
Closures handled: screw caps, dropper assembly, aluminum caps
Production output: up to 50 containers/minute
SC50T

Provides uniform tightening of container caps up to 95mm in diameter and provides gentle cap handling. This machine is ideal for lab use.

SC50T

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PS Series Plug Sealing
Functions: seats closures
Container movement: manual
Speed: up to 60 containers/minute depending on operator
Closures handled: plugs, caps and other forms of "snap-in" or "press-on" closures
PS1 Designed to seat plugs, caps and other forms of "snap-in" or "press-on" closures that have been placed upon open containers.
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RS Series Stopperer
Functions: stoppers
Speed: 100 - 400 containers/minute
Closures handled: conventional, slotted, or fluted stoppers depending on model
Stopper movement: intermittent or continuous depending on model
Stopper sizes handled: 13mm, 20mm, 28mm, 30mm, 32mm
RS400

The RS Series can be furnished with a special stoppering head to handle dispenser plugs, such as those used to restrict the flow of topical solutions. Ideally suited for cleanroon environments, the RS Series offers full insertion and full or partial insertion, depending on the model of stoppers at speeds up to 400 containers/minute.

RS

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CM Series High-Speed Rotary Crimping Limited Production
Functions: crimp seal
Container movement: continuous
Speed: up to 400 containers/minute
Closure sizes: 13mm to 32mm
Closures handled: aluminum caps
Production output: Up to 400 Containers per Minute
CM200

Our CM Series handles stoppered containers with absolute control while it automatically caps and crimp seals aluminum closures. As capped containers index into position individual single-roller crimping heads lower adn tuck the skirt under with a gentle progressive roll, then raise as finished containers index out.

CM

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CM60A Crimp Sealing Limited Production
Functions: crimp seal
Container movement: intermittent
Speed: up to 60 containers/minute
Closures handled: aluminum caps
Our CM60A automatically places and crimp seals aluminum closures at speeds up to 60 containers per minute.
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Tray Loading
Cozzoli tray loaders provide high speed performance while maintaining positive vial control at all times.

BT400 Robotic Pick and Place Tray Loading
Functions: tray load vials
Container movement: continuous
Container diameters handled: 1/2" - 21/2"
Speed: up to 20 rows/minute
Closures handled: conventional, slotted
Tray type handled: three or four sided
BT400 Our BT400 container-handling model offers the latest technical advancements in robotic automation. It's unique robotic arm picks up vials by the side of their necks, thus eliminating particle-generating mechanisms like pivots, linkages or slides over the vials.
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BT15 Automatic Tray Loader
Functions: tray load vials
Container movement: intermittent
Container diameters handled: 1/2" - 21/2"
Speed: up to 20 rows/minute
Tray type handled: three sided
BT15

The BT15 is another fine example of vial transfer. It incorporates an infeed conveyor that directs containers into a dual-tray staging area where rows of vials are placed into three-sided trays.

BT15

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Syringe Filling/Stoppering

MVP Vacuum Stopperer
Functions: inserts closures into filled containers
Container movement: manual
Closures handled: stoppers, plungers, plugs
Production output: up to 200 containers/minute
MVP

This vacuum stoppering unit efficiently inserts stoppers, plungers or plugs into multiple filled syringes.

MVP

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F329-HA-10
Functions: fill
Container movement: intermittent
Container handling: pre-packaged Hypak
Containers handled: Hypak placed manually in machine
Number of fill stations: 10
Accuracy: +/- 1/2 of 1% of fill volume
This unit is specifically designed to fill Hypak syringes. Operating mechanically, the carrier mechanism is designed for various syringe formats such as 10x10, 8x8, 6x7 and 5x6. It is designed to dispense a broad range of liquids ranging from aqueous solutions to creams. All product contact parts are easily removed for autoclaving.
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F329-HE-10
Functions: fill
Container movement: intermittent
Container handling: batch
Containers handled: B-D Hypak syringes
Speed: 1 tub at 35 seconds
Number of fill stations: 10
Accuracy: +\- 1/2 of 1% of fill volume
F329HE The F329HE is an electronic syringe filling machine, designed to provide moderate production output in a batch filling operation. This machine can be preprogrammed for various syringe formats such as 10x10, 8x8, 6x7 and 5x6. The programmable PLC allows you to easily select your specific fill pattern.

Unscrambling/Accumulating Tables
These rotary tables are equipped with stainless steel turntables, and designed to provide smooth unscrambling or accumulating of a broad variety of containers such as vials, jars, bottles or cans made out of glass, plastic or metal.

Accumulating Tables
Functions: Accumulate
Container movement: Continuous
The accumulating tables are available in 4 sizes, AT30, AT36, AT42 and AT48. Accumulators can be located at any point on the production line where either smooth transfer between machines and/or accumulation is required.
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Unscrambling Tables
Functions: Unscramble
Container movement: Continuous
Containers handled: Vials, Bottles, Cans
Cozzoli's unscrambling tables are available in 4 models - UT30, UT36, UT42 and UT48. The unscrambling tables are positioned at the start of conveyorized production line for imparting inital flow to containers.
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Validation Protocols
One easy way to assure regulatory compliance is choosing COZZOLI Validation Protocols. The protocols can be written for one piece of equipment, for multiple or for an entire line. Protocols can also be written for Cozzoli made equipment, for integrated equipment or other equipment as well.

Protocols
FAT : Factory Acceptance Test
SAT: Site Acceptance Test
IQ: Installation Qualification
OQ: Operational Qualification
PQ: Performance Qualification
Cozzoli offers Technical Support Service for protocol execution. Contact Customer Service or Sales for details, as protocols vary very much with equipment.
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